Description

Chloro(1,1-dimethylethyl)[1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]phosphine is a specialized organophosphorus compound featuring a sterically hindered tertiary phosphine ligand. This compound is valued for its unique structural framework, which combines a neopentyl-like chloro-tert-butylphosphine group with a bulky, chiral bornyl moiety derived from camphor. It serves as a highly effective ligand precursor in advanced catalytic systems, particularly for transition metal complexes used in asymmetric synthesis and cross-coupling reactions. Industrial and academic researchers in fine chemical, pharmaceutical, and advanced materials sectors utilize this reagent to develop novel catalytic processes requiring precise stereochemical control and enhanced reactivity.

Application

• Asymmetric Catalysis: As a chiral, bulky phosphine ligand precursor for transition metals (e.g., Pd, Rh, Ru) in enantioselective hydrogenation, hydroformylation, and C-C bond-forming reactions.
• Pharmaceutical Intermediates: Enabling the synthesis of complex, chiral active pharmaceutical ingredients (APIs) where stereoselectivity is critical.
• Advanced Material Synthesis: Facilitating the production of specialized polymers and organic electronic materials through controlled metal-mediated polymerization.
• Organometallic Chemistry Research: Serving as a key building block for synthesizing novel metal complexes with tailored steric and electronic properties for catalytic study.
• Agrochemical Development: Used in the research and synthesis of chiral, biologically active molecules for crop protection agents.
• Ligand Library Development: A valuable component in high-throughput screening libraries for discovering new catalytic transformations.

Basic Information

Product Name	Chloro(1,1-dimethylethyl)[1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]phosphine
CAS No.	74630-34-5
Molecular Formula	C₁₄H₂₆ClP
Molecular Weight	260.78 g/mol
Synonyms	Chloro(tert-butyl)(2-bornyl)phosphine; tert-Butyl(2-bornyl)chlorophosphine; 2-Bornyl-tert-butylchlorophosphine; (1R,2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl(chloro)(tert-butyl)phosphine; Chloro-tert-butylbornylphosphine; P-Chloro-P-tert-butylbornane; tert-Butylbornylphosphinous chloride; (2-Bornyl)chloro(tert-butyl)phosphine
EINECS	Contact for details

Quality Control

Our Chloro(1,1-dimethylethyl)[1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]phosphine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ³¹P) and HPLC or GC analysis, to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to supplying material that meets the exacting standards required for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Allow the container to reach ambient temperature before opening to prevent moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (typical)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.