Description

Chloro(Phenyl)[1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl]phosphine is a specialized organophosphorus compound featuring a unique chiral camphor-derived backbone. This compound matters as a highly effective chiral ligand and catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure molecules. It is primarily needed by manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing advanced intermediates and active ingredients.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metal-catalyzed reactions, including hydrogenation, hydrosilylation, and cross-coupling.
• Pharmaceutical Intermediates: Synthesis of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Key reagent in the synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic & Industrial Research: A valuable tool for methodology development in organic and organometallic chemistry.
• Material Science: Potential precursor for chiral polymers or advanced materials with specific optical properties.

Basic Information

Product Name	Chloro(Phenyl)[1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl]phosphine
CAS No.	74630-27-6
Molecular Formula	C₁₆H₂₂ClP
Molecular Weight	280.77 g/mol
Synonyms	Chloro(phenyl)(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)phosphine; (1R,2S,5R)-Chloro(phenyl)(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)phosphine; (-)-Camphor-based chlorophosphine ligand; (1R)-(-)-Chloro(phenyl)neomenthylphosphine; P-Chloro-P-phenylneomenthylphosphine; Neomenthylphenylphosphinous chloride; (1R,2S,5R)-2-(Chloro(phenyl)phosphanyl)-1,7,7-trimethylbicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our Chloro(Phenyl)[1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl]phosphine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity, chiral integrity, and consistent performance. Certificates of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles are provided with each shipment. We adhere to relevant cGMP and ISO 9001 standards for research and industrial-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. The compound is sensitive to moisture and oxygen; handle and package using standard techniques for air-sensitive materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.