Description

Proline, 2-Ethynyl-5-Oxo- (9Ci) is a specialized, non-proteinogenic proline derivative featuring an ethynyl substituent at the 2-position and a carbonyl group at the 5-position. This unique molecular architecture makes it a valuable high-purity building block for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the creation of novel bioactive compounds, peptidomimetics, and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics Research: Used to introduce constrained, alkyne-functionalized proline analogs into peptide chains to modulate biological activity, stability, and conformation.
• Chemical Biology Probes: Acts as a precursor for "click chemistry" applications via its ethynyl group, enabling bioconjugation and labeling strategies in proteomics and diagnostics.
• Organic Synthesis Building Block: Employed in the synthesis of complex heterocycles and natural product analogs due to its reactive functional groups.
• Agrochemical Research: Investigated as a potential intermediate for developing novel, biologically active compounds in crop protection.
• Academic & Industrial R&D: A critical reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Proline, 2-Ethynyl-5-Oxo- (9Ci)
CAS No.	74580-20-4
Molecular Formula	C7H7NO2
Molecular Weight	137.14 g/mol
Synonyms	2-Ethynyl-5-oxopyrrolidine-2-carboxylic acid; 5-Oxo-2-ethynylproline; 2-Ethynyl-5-oxo-L-proline; 2-Ethynyl-5-pyrrolidone-2-carboxylic acid; (S)-2-Ethynyl-5-oxopyrrolidine-2-carboxylic acid; 2-Ethynyl-5-oxo-DL-proline; 74580-20-4
EINECS	Contact for details

Quality Control

Our Proline, 2-Ethynyl-5-Oxo- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistent performance. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry for identity confirmation and purity assessment. Our quality commitment aligns with the standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.