Description

Endoproteinase Pro-C is a highly specific proteolytic enzyme, also known as Pro-Protein Convertase, with the CAS Registry Number 74506-45-9. This enzyme is critical for the precise cleavage of precursor proteins at specific paired basic amino acid residues, enabling the activation of numerous biologically important peptides and hormones. It is an essential research and production tool for biotechnology, pharmaceutical development, and diagnostic applications where controlled protein processing is required.

Application

• Biopharmaceutical Research & Development: Used for the activation of recombinant protein therapeutics and the study of prohormone and proprotein processing pathways.
• Peptide Synthesis & Processing: Employed in the final cleavage and purification steps of synthetic peptides to generate active biological sequences.
• Diagnostic Assay Development: Serves as a key reagent in enzymatic assays designed to detect and quantify specific protease activities or their inhibitors.
• Cell Biology & Signal Transduction Studies: Utilized to investigate the role of proprotein convertases in cellular differentiation, disease mechanisms, and metabolic regulation.
• Enzyme Characterization: Acts as a standard or reference material for the biochemical characterization of other proteases and for inhibitor screening.

Basic Information

Product Name	Endoproteinase Pro-C
CAS No.	74506-45-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pro-Protein Convertase; Paired Basic Amino Acid Cleaving Enzyme; PACE; Furin; Subtilisin/Kexin-like Protease; Prohormone Convertase; PC; Endoprotease Pro-C
EINECS	Contact for details

Quality Control

Our Endoproteinase Pro-C is produced and tested under stringent quality management systems. Each batch is characterized for specific activity, purity, and absence of contaminating proteases to ensure reproducible performance in sensitive applications. A comprehensive Certificate of Analysis (COA) detailing assay results, purity by HPLC, and specific activity is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Cleaves specific fluorogenic peptide substrate
Specific Activity	≥ [Value] units/mg protein
Purity (SDS-PAGE)	≥ 95%
Protein Content (Bradford)	Reported on COA
Endotoxin Level	< 1.0 EU/μg (for research-grade)
Solubility	Soluble in aqueous buffers or provided reconstitution solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.