Description

α-Dendrotoxin is a potent and selective polypeptide neurotoxin isolated from the venom of the Eastern green mamba (*Dendroaspis angusticeps*). This high-purity biochemical is a critical research tool for studying voltage-gated potassium (Kv) channels in neuronal and cellular systems. It is essential for neuroscientists, pharmacologists, and biochemists engaged in fundamental neurological research, ion channel characterization, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Selective blockade of specific subtypes of voltage-gated potassium channels (Kv1.1, Kv1.2, Kv1.6) to study neuronal excitability and synaptic transmission.
• Ion Channel Pharmacology: Used as a reference standard and pharmacological probe for characterizing Kv channel function, distribution, and modulation in various cell types.
• Drug Discovery & Development: A key tool in high-throughput screening assays and target validation for neurological disorders such as epilepsy, multiple sclerosis, and neuropathic pain.
• Biochemical Studies: Investigation of toxin-receptor interactions, structure-activity relationships (SAR), and the mechanisms of neurotoxicity.
• Academic & Institutional Research: Fundamental research in university and government laboratories focusing on cellular electrophysiology and signal transduction pathways.

Basic Information

Product Name	α-Dendrotoxin
CAS No.	74504-53-3
Molecular Formula	C~184~H~282~N~52~O~55~S~7
Molecular Weight	Approx. 4200 Da
Synonyms	Dendrotoxin I; DTX-I; DTX; Toxin I (Dendroaspis angusticeps); Dendrotoxin-alpha; α-Dendrotoxin; Potassium channel toxin α-DTx; ShK-like toxin 1
EINECS	Contact for details

Quality Control

Our α-Dendrotoxin is produced and purified under stringent conditions to ensure the highest levels of biological activity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry for identity confirmation, and functional bioassays to verify potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and endotoxin levels.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with α-Dendrotoxin
Purity (HPLC)	≥ 95%
Potency (Bioassay)	≥ 98%
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.