Description

4-(Trifluoromethylthio)Benzyl Chloride is a versatile and high-value organofluorine building block essential for advanced chemical synthesis. Its unique structure, featuring both a reactive benzyl chloride group and a trifluoromethylthio moiety, makes it a critical intermediate for introducing lipophilic and electron-withdrawing properties into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing candidates for central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylthio group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing specialty chemicals used in electronic displays and organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: Employed in organic and organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis.
• Functional Material Research: A valuable reagent in materials science for modifying polymer backbones and creating advanced functional materials with specific surface properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	4-(Trifluoromethylthio)Benzyl Chloride
CAS No.	74483-45-7
Molecular Formula	C8H6ClF3S
Molecular Weight	226.64 g/mol
Synonyms	α-Chloro-4-(trifluoromethylthio)toluene; 1-(Chloromethyl)-4-(trifluoromethylthio)benzene; p-(Trifluoromethylthio)benzyl chloride; 4-(Trifluoromethylsulfanyl)benzyl chloride; (4-(Trifluoromethylthio)phenyl)methyl chloride; Benzene, 1-(chloromethyl)-4-[(trifluoromethyl)thio]-
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylthio)Benzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.