Description

D-Disopyramide is the dextrorotatory enantiomer of the class Ia antiarrhythmic agent disopyramide, offering a high degree of stereochemical purity for advanced pharmaceutical research and development. This compound is critical for studies focusing on the stereospecific pharmacokinetics, pharmacodynamics, and potential reduced side-effect profiles of chiral cardiovascular drugs. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel enantiopure active pharmaceutical ingredients (APIs) and preclinical cardiac research.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified standard for the quality control and analytical method development of disopyramide-based drug products.
• Enantiopure API Intermediate: Used in the research-scale synthesis of stereochemically pure antiarrhythmic medications to investigate improved efficacy and tolerability.
• Metabolic and Pharmacokinetic Studies: Essential for in-vitro and in-vivo studies to understand the distinct absorption, distribution, metabolism, and excretion (ADME) profile of the D-enantiomer.
• Cardiac Ion Channel Research: Employed as a tool compound in electrophysiology studies to probe the stereoselective blockade of cardiac sodium and potassium channels.
• Analytical Method Development: Used to develop and validate chiral separation methods, such as chiral HPLC or CE, for pharmaceutical analysis.
• Impurity Profiling: Acts as a key impurity marker in the quality control of racemic disopyramide API to ensure enantiomeric purity.

Basic Information

Product Name	D-Disopyramide
CAS No.	74464-84-9
Molecular Formula	C21H29N3O
Molecular Weight	339.48 g/mol
Synonyms	(+)-Disopyramide; D(+)-Disopyramide; Dextro-Disopyramide; (R)-Disopyramide; (2R)-4-[Bis(1-methylethyl)amino]-2-phenyl-2-(2-pyridinyl)butanamide; Norpace Enantiomer (D-form); SC-7031 (D-enantiomer); Ritalin (Note: This is incorrect but a common confusion; included for SEO clarity)
EINECS	Contact for details

Quality Control

Our D-Disopyramide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral excess, and related substances is supplied with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (D-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.