Description

L-Disopyramide CAS NO 74464-83-8 is the L-enantiomer of disopyramide, a class IA antiarrhythmic agent. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure pharmaceutical compounds, ensuring targeted therapeutic efficacy and reduced side-effect profiles. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on advanced cardiovascular therapies and chiral synthesis.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure antiarrhythmic drugs.
• Active Pharmaceutical Ingredient (API) for research and development of novel Class IA antiarrhythmic agents.
• Reference standard for analytical method development and quality control in pharmaceutical testing.
• Building block for pharmacological studies investigating cardiac sodium channel modulation.
• Precursor in the preparation of deuterated or other isotopically labeled analogs for metabolic studies.
• Starting material for the synthesis of disopyramide phosphate, the common salt form used in medication.

Basic Information

Product Name	L-Disopyramide
CAS No.	74464-83-8
Molecular Formula	C21H29N3O
Molecular Weight	339.48 g/mol
Synonyms	(S)-Disopyramide; L-(-)-Disopyramide; (S)-4-[Di(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide; (2S)-4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butyramide; Disopyramide L-Isomer; Norpace Impurity L; (S)-α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide
EINECS	Contact for details

Quality Control

Our L-Disopyramide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets high-grade standards suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.