Description

4-(Trifluoromethyl)Phenylacetyl Chloride is a versatile and highly reactive organofluorine building block. This compound is valued for its ability to introduce the 4-(trifluoromethyl)phenylacetyl moiety, a key structural motif that enhances the lipophilicity and metabolic stability of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical reagent for synthesizing drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a key starting material for creating fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Peptide & Protein Modification: Employed as an acylating agent to introduce fluorinated aromatic groups into peptides and biomolecules for research and diagnostic applications.
• Polymer & Resin Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with enhanced chemical resistance and thermal stability.
• Organic Synthesis & Catalysis Research: A fundamental building block in academic and industrial research for developing new fluorination methodologies and catalytic processes.

Basic Information

Product Name	4-(Trifluoromethyl)Phenylacetyl Chloride
CAS No.	74426-51-0
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	2-[4-(Trifluoromethyl)phenyl]acetyl chloride; 4-(Trifluoromethyl)benzeneacetyl chloride; p-(Trifluoromethyl)phenylacetyl chloride; α-Chloro-4-(trifluoromethyl)phenylacetyl chloride; 2-(4-Trifluoromethylphenyl)acetyl chloride; (4-Trifluoromethylphenyl)acetyl chloride; 4-Trifluoromethylbenzeneacetyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Phenylacetyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity, and impurity profiles via validated methods such as GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and handled under dry conditions to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.