Description

L-Valine Methylamide Hcl is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group compatibility for complex molecule construction. It is primarily utilized in the pharmaceutical industry for the research and development of novel active pharmaceutical ingredients (APIs), particularly in peptide mimetics and other bioactive compounds. Its defined structure and high purity make it a valuable intermediate for applications demanding strict quality control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates, especially peptide-based therapeutics and enzyme inhibitors.
• Peptidomimetic Research: Serves as a constrained amino acid analog for developing metabolically stable peptide mimics with enhanced bioavailability.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes to study enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chiral centers.
• Agrochemical Development: Potential intermediate in the synthesis of chiral, biologically active compounds for crop protection.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	L-Valine Methylamide Hcl
CAS No.	74410-26-7
Molecular Formula	C6H15ClN2O
Molecular Weight	166.65 g/mol
Synonyms	L-Valine, N-methylamide, hydrochloride; (S)-2-Amino-3-methylbutanamide, N-methyl-, hydrochloride; Valine methylamide hydrochloride; L-Valine Methyl Amide Hydrochloride; (S)-2-Amino-N-methyl-3-methylbutanamide hydrochloride; Methyl-L-valinamide hydrochloride; N-Methyl-L-valinamide hydrochloride; L-N-Methylvalinamide HCl
EINECS	Contact for details

Quality Control

Our L-Valine Methylamide Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.