Description

Z-Tyr(Tbu)-Onp is a protected tyrosine derivative widely used as a key synthetic intermediate in peptide chemistry. Its primary value lies in enabling the controlled, sequential construction of complex peptides by protecting reactive functional groups during synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic peptides and conducting advanced biochemical research. Its specific protection scheme offers critical advantages in yield and purity for demanding synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial building block for the incorporation of tyrosine residues using the Fmoc/t-Bu strategy.
• Solution-Phase Peptide Synthesis: Used in the classical synthesis of peptide fragments and small peptides in solution.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: The activated ester (Onp) group facilitates the selective coupling of tyrosine-containing peptides to other molecules, such as fluorophores or polymers.
• Biochemical Research: Employed in academic and industrial labs for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Custom Peptide Service: A fundamental reagent for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis.

Basic Information

Product Name	Z-Tyr(Tbu)-Onp
CAS No.	74293-19-9
Molecular Formula	C25H30N2O7
Molecular Weight	470.52 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-tyrosine 4-nitrophenyl ester; Fmoc-Tyr(tBu)-ONp; Z-O-tert-Butyl-L-tyrosine p-nitrophenyl ester; N-Carbobenzoxy-O-tert-butyl-L-tyrosine p-nitrophenyl ester; Fmoc-L-tyrosine(O-t-butyl)-4-nitrophenyl ester; Benzyloxycarbonyl-O-tert-butyltyrosine p-nitrophenyl ester; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxy)phenyl)propanoic acid 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-Tyr(Tbu)-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.