Description

Boc-Asp-Nh2 CAS NO 74244-17-0 is a protected derivative of aspartic acid, featuring a tert-butoxycarbonyl (Boc) protecting group on the α-amino functionality. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it prevents unwanted side reactions during the sequential assembly of peptide chains. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of therapeutic peptides, peptide hormones, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled assembly of peptide sequences.
• Pharmaceutical Intermediates: In the research and production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation: For the chemical modification of proteins or other biomolecules, leveraging the reactivity of the protected aspartic acid side chain.
• Organic Synthesis: As a chiral synthon or building block for the construction of non-peptide molecules with complex stereochemistry.
• Research & Development: In academic and industrial labs for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	Boc-Asp-Nh2
CAS No.	74244-17-0
Molecular Formula	C9H16N2O5
Molecular Weight	232.24 g/mol
Synonyms	Nα-Boc-L-asparagine; Boc-L-Asn-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-4-carbamoylbutanoic acid; Boc-Asn-OH; N-tert-Butoxycarbonyl-L-asparagine; Boc-Asparagine; L-Asparagine, N-(1,1-dimethylethoxy)carbonyl]-; BOC-ASN
EINECS	Contact for details

Quality Control

Our Boc-Asp-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high-purity standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.