Description

(1S,5R)-3-Benzhydryloxy-8-Methyl-8-Azabicyclo[3.2.1]Octane, 3-(2-Chlor Ophenothiazin-10-Yl)-N,n-Dimethyl-Propan-1-Amine, Methanesulfonic Acid is a high-purity, complex organic salt with significant pharmacological relevance. This compound serves as a critical intermediate or reference standard in the development and quality control of active pharmaceutical ingredients (APIs). It is essential for research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on neuropharmacology and psychotropic drug development, where precise chemical structure and purity are paramount for efficacy and safety studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced therapeutic agents, particularly in the central nervous system (CNS) category.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories.
• Research & Development: Critical for preclinical and clinical research studies investigating new drug candidates and their mechanisms of action.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex final drug substances requiring high stereochemical purity.
• Process Chemistry: Serves as a standard for optimizing synthetic routes and scaling up production in process development.
• Metabolite Studies: Utilized in the identification and analysis of drug metabolites during pharmacokinetic and toxicological research.

Basic Information

Product Name	(1S,5R)-3-Benzhydryloxy-8-Methyl-8-Azabicyclo[3.2.1]Octane, 3-(2-Chlor Ophenothiazin-10-Yl)-N,n-Dimethyl-Propan-1-Amine, Methanesulfonic Acid
CAS No.	74195-64-5
Molecular Formula	C32H37ClN2O4S
Molecular Weight	581.17 g/mol
Synonyms	Benztropine Mesylate (related salt); 3α-(Diphenylmethoxy)-1αH,5αH-tropane Methanesulfonate; 8-Methyl-3-benzhydryloxy-8-azabicyclo[3.2.1]octane Methanesulfonate; Tropine Benzohydryl Ether Methanesulfonate; (1S,5R)-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate; 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine methanesulfonate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical ingredients, and specifications can be aligned with client-specific pharmacopeial requirements (USP/EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.