Description

Trifluoromethylacetate is a versatile fluorinated building block and reagent essential for advanced organic synthesis. Its primary value lies in introducing the highly electronegative trifluoromethyl group, which can dramatically alter the physical, chemical, and biological properties of target molecules. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing the CF3 moiety, enhancing drug potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science: Serves as a precursor for fluorinated monomers and polymers, contributing to materials with unique surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: Employed in nucleophilic trifluoromethylation reactions and as an acylating agent under specific conditions in complex molecule construction.
• Liquid Crystal & Electronic Chemicals: Used in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric fluids.

Basic Information

Product Name	Trifluoromethylacetate
CAS No.	74123-20-9
Molecular Formula	C3H3F3O2
Molecular Weight	128.05 g/mol
Synonyms	Acetic acid, trifluoromethyl ester; Trifluoromethyl acetate; Methyl trifluoroacetate (common misnomer, verify structure); CF3COOCH3; Trifluoroacetic acid methyl ester; TFA Methyl Ester; Methyl ester of trifluoroacetic acid; 2,2,2-Trifluoroacetate methyl ester
EINECS	Contact for details

Quality Control

Our Trifluoromethylacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including GC/HPLC for purity and identity confirmation to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, oxidizing agents, and moisture. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent volatility and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.3 g/mL
Boiling Point	~40-45°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.