Description

Ethyl 2,2-Difluorohexanoate is a specialized fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the gem-difluoro group adjacent to the carbonyl, enabling the introduction of fluorinated motifs into target molecules. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly those targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, where fluorine atoms can enhance biological activity and environmental stability.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing fluorinated polymers, liquid crystals, or specialty surfactants with unique surface properties.
• Organic Synthesis Building Block: Employed in nucleophilic substitution, condensation, and reduction reactions to construct complex, fluorinated molecular architectures.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by providing a versatile handle for introducing difluoroalkyl chains.

Basic Information

Product Name	Ethyl 2,2-Difluorohexanoate
CAS No.	74106-81-3
Molecular Formula	C8H14F2O2
Molecular Weight	180.19 g/mol
Synonyms	2,2-Difluorohexanoic Acid Ethyl Ester; Ethyl 2,2-Difluorocaproate; Hexanoic acid, 2,2-difluoro-, ethyl ester; Ethyl α,α-Difluorohexanoate; Ethyl 2,2-Difluoro-n-hexanoate
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluorohexanoate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports traceability and is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly closed and stored in a dry inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.08 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.