Description

Tris(α,α,α-Trifluoro-m-Tolyl)Phosphine Oxide is a specialized organophosphorus compound featuring three electron-withdrawing trifluoromethylphenyl groups. This unique structure makes it a highly effective ligand and catalyst component in demanding synthetic transformations, particularly in cross-coupling reactions. It is essential for researchers and process chemists in the pharmaceutical and advanced materials sectors who require precise control over metal-catalyzed processes. Its stability under basic conditions makes it suitable for challenging synthetic routes.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi) for constructing complex drug molecules.
• Advanced Material Research: Used in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where fluorine-containing ligands enhance performance.
• Catalyst Development: Serves as a precursor or supporting ligand for homogeneous catalysts in fine chemical and specialty polymer production.
• Organic Synthesis Reagent: Employed as a stabilizing ligand for organometallic complexes in air- and moisture-sensitive reactions.
• Agrochemical Research: Potential use in the synthesis of novel, high-performance active ingredients requiring fluorinated components.

Basic Information

Product Name	Tris(α,α,α-Trifluoro-m-Tolyl)Phosphine Oxide
CAS No.	74038-21-4
Molecular Formula	C21H12F9OP
Molecular Weight	482.28 g/mol
Synonyms	Tris(3-(Trifluoromethyl)phenyl)phosphine Oxide; Tris(m-Trifluoromethylphenyl)phosphine Oxide; (3-(Trifluoromethyl)phenyl)phosphine Oxide, Tris-; Phosphine Oxide, Tris[3-(trifluoromethyl)phenyl]-; Tris(3-Trifluoromethylphenyl)Phosphine Oxide; P,P,P-Tris(3-Trifluoromethylphenyl)phosphine Oxide; Tris(α,α,α-Trifluoro-m-tolyl)phosphine; TOFPO (common abbreviation)
EINECS	Contact for details

Quality Control

Our production of Tris(α,α,α-Trifluoro-m-Tolyl)Phosphine Oxide adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.