Description

Thymidine-5'-Tri-3'-Diphosphate is a specialized nucleotide analog of significant biochemical and pharmacological interest. This compound serves as a crucial tool in enzymatic studies and the development of novel therapeutic agents, particularly in antiviral and anticancer research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for probing DNA/RNA metabolism and as a precursor for nucleotide-based prodrugs.

Application

• Biochemical Research: Used as a substrate or inhibitor in studies of DNA polymerases, reverse transcriptases, and other nucleic acid-metabolizing enzymes.
• Antiviral Drug Development: Serves as a key intermediate or active metabolite in the synthesis of nucleoside analog prodrugs targeting viral replication.
• Oncology Research: Investigated for its potential role in cancer therapy, particularly in mechanisms involving DNA synthesis inhibition.
• Diagnostic Assays: Employed in the development of enzymatic assays and diagnostic kits for monitoring specific enzymatic activities.
• Metabolic Pathway Studies: Utilized to trace and understand nucleotide salvage pathways and intracellular nucleotide metabolism.
• Synthetic Biology: Acts as a building block for the synthesis of modified oligonucleotides with specific biological functions.

Basic Information

Product Name	Thymidine-5'-Tri-3'-Diphosphate
CAS No.	73909-63-4
Molecular Formula	C10H17N2O14P3
Molecular Weight	506.16 g/mol
Synonyms	dTTP-3'-diphosphate; 3'-dTDP-5'-triphosphate; Thymidine 5'-(trihydrogen triphosphate) 3'-(trihydrogen diphosphate); P1-(5'-Thymidyl)-P3-(3'-thymidyl) triphosphate; TDPTP; Thymidine 5'-triphosphoric acid 3'-diphosphoric acid; 2'-Deoxythymidine 5'-triphosphate 3'-diphosphate
EINECS	Contact for details

Quality Control

Our Thymidine-5'-Tri-3'-Diphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectral data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water or suitable aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.