Description

3,5-Bis(Trifluoromethyl)Benzeneboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Material Science: Serves as a monomer or precursor for creating specialty polymers, liquid crystals, and organic electronic materials with unique optical or electrical properties.
• Catalyst Ligand Precursor: Employed in the synthesis of sophisticated ligand systems for transition metal catalysts used in fine chemical manufacturing.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new carbon-carbon bond-forming methodologies and creating compound libraries for screening.
• Fluorinated Compound Synthesis: Essential for introducing the highly sought-after trifluoromethylphenyl moiety into target molecules, a common motif in modern drug design.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzeneboronic Acid
CAS No.	73852-19-4
Molecular Formula	C8H5BF6O2
Molecular Weight	257.93 g/mol
Synonyms	[3,5-Bis(trifluoromethyl)phenyl]boronic acid; 3,5-Bis(trifluoromethyl)phenylboronic acid; Benzeneboronic acid, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)benzeneboronic acid; (3,5-Bis(trifluoromethyl)phenyl)boronic acid; 3,5-Bis(trifluoromethyl)benzeneboronic acid pinacol ester (precursor); 3,5-(CF3)2C6H3B(OH)2
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee supply reliability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.