Description

(1R,5S)-8-[3-(2-Chloro-10H-Phenothiazin-10-Yl)Propyl]-8-Azabicyclo[3.2.1]Octan-3β-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its complex bicyclic structure. This compound is critical for the synthesis of specialized active pharmaceutical ingredients (APIs) targeting neurological and psychiatric pathways. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antipsychotic and neuroleptic drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Preclinical Studies: Employed in the production of compounds for pharmacological evaluation and toxicology assessments.
• Process Chemistry: Utilized in route scouting and scale-up optimization for efficient API production.

Basic Information

Product Name	(1R,5S)-8-[3-(2-Chloro-10H-Phenothiazin-10-Yl)Propyl]-8-Azabicyclo[3.2.1]Octan-3β-Ol
CAS No.	73805-93-3
Molecular Formula	C22H25ClN2OS
Molecular Weight	400.96 g/mol
Synonyms	3β-Hydroxy-8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-8-azabicyclo[3.2.1]octane; 8-Azabicyclo[3.2.1]octan-3β-ol, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-; (3-endo)-8-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-8-azabicyclo[3.2.1]octan-3-ol; 2-Chloro-10-[3-(3β-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)propyl]phenothiazine
EINECS	Contact for details

Quality Control

Our (1R,5S)-8-[3-(2-Chloro-10H-Phenothiazin-10-Yl)Propyl]-8-Azabicyclo[3.2.1]Octan-3β-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.