Description

Ethyl 2,2-Difluoro-2-(4-(Trifluoromethyl)Phenyl)Acetate is a high-value fluorinated aromatic ester, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both difluoroacetate and trifluoromethylphenyl moieties, makes it an essential building block for introducing fluorine atoms into target molecules, thereby enhancing their metabolic stability, lipophilicity, and binding affinity. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic compounds for electronic displays and organic light-emitting diodes.
• Advanced Polymer Chemistry: Employed to incorporate fluorine into polymer backbones or side chains, modifying surface properties, chemical resistance, and thermal stability.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new fluorination methodologies and creating complex molecular architectures.
• Specialty Chemical Manufacturing: Intermediate for producing other high-value fluorinated fine chemicals and performance materials.

Basic Information

Item	Details
Product Name	Ethyl 2,2-Difluoro-2-(4-(Trifluoromethyl)Phenyl)Acetate
CAS No.	73789-96-5
Molecular Formula	C11H9F5O2
Molecular Weight	268.18 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetate; 2,2-Difluoro-2-(4-trifluoromethylphenyl)acetic Acid Ethyl Ester; α,α-Difluoro-4-(trifluoromethyl)phenylacetic Acid Ethyl Ester; Ethyl α,α-Difluoro-4-(trifluoromethyl)phenylacetate; 73789-96-5; Ethyl 4-(Trifluoromethyl)benzoyldifluoroacetate (related); Ethyl (4-Trifluoromethylphenyl)difluoroacetate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2,2-Difluoro-2-(4-(Trifluoromethyl)Phenyl)Acetate is manufactured under a strict quality management system. We employ advanced analytical techniques, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specification parameters is provided with each shipment to guarantee traceability and support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.