Description

Nitrosocimetidine is a specialized organic compound of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis and analytical profiling of related active pharmaceutical ingredients. It is primarily utilized by research institutions and chemical manufacturers engaged in advanced medicinal chemistry and process development. The material is supplied with a focus on high purity and consistency to support rigorous scientific applications.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of H₂-receptor antagonist analogs and related therapeutic agents.
• Analytical Reference Standard: Used for method development, validation, and quality control testing in pharmaceutical analysis (e.g., HPLC, LC-MS).
• Metabolite Studies: Employed in pharmacological and toxicological research to investigate drug metabolism pathways.
• Process Chemistry Research: A valuable building block for exploring novel synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).
• Impurity Profiling: Serves as a certified reference material for identifying and quantifying potential nitrosamine impurities in pharmaceutical products, supporting regulatory compliance.

Basic Information

Product Name	Nitrosocimetidine
CAS No.	73785-40-7
Molecular Formula	C10H16N6OS
Molecular Weight	268.34 g/mol
Synonyms	N-Nitrosocimetidine; Cimetidine Nitroso Derivative; N-Nitroso-Cimetidine; 1-Cyano-2-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, N-nitroso-; NSC 339024; Nitrosated Cimetidine
EINECS	Contact for details

Quality Control

Our Nitrosocimetidine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Quality assurance protocols are designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.