Description

Pentobarbital-D5 is a deuterium-labeled analog of the barbiturate derivative pentobarbital, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is primarily utilized by pharmaceutical researchers, forensic toxicologists, and contract research organizations (CROs) engaged in method development, pharmacokinetic studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of pentobarbital in bioanalytical assays, correcting for matrix effects and instrument variability.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of pentobarbital.
• Forensic Toxicology: Enables accurate measurement of pentobarbital concentrations in post-mortem and clinical samples for legal and medical investigations.
• Reference Standard: Serves as a certified reference material for calibrating analytical instruments and validating testing methodologies.
• Veterinary Medicine Research: Applied in studies investigating the use and metabolism of pentobarbital in animals.
• Stable Isotope Labeling Studies: Facilitates research into metabolic pathways and the environmental fate of barbiturate compounds.

Basic Information

Product Name	Pentobarbital-D5
CAS No.	73738-05-3
Molecular Formula	C11H13D5N2O3
Molecular Weight	230.28 g/mol
Synonyms	5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-d5; Pentobarbital-d5; 5-Ethyl-5-(1-methylbutyl)barbituric acid-d5; Nembutal-d5 (labeled analog); Pentobarbital (ethyl-d5); Deuterated Pentobarbital
EINECS	Contact for details

Quality Control

Our Pentobarbital-D5 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant quality guidelines for high-purity fine chemicals used in research and analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.