Description

Fmoc-L-Serine CAS NO 73724-45-5 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its primary value lies in the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which provides orthogonal protection for the amine functionality and can be cleanly removed under mild basic conditions. This compound is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality reagents for the production of peptides, peptidomimetics, and other bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the Fmoc-strategy synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic peptides targeting various diseases.
• Bioconjugation and Labeling: The reactive carboxyl and protected amine groups allow for site-specific modification and labeling of biomolecules.
• Combinatorial Chemistry Libraries: A key component in generating diverse libraries of serine-containing compounds for drug discovery screening.
• Glycopeptide Synthesis: Serves as a precursor for introducing O-linked glycosylation sites into synthetic peptides.
• Academic and Industrial Research: Essential reagent for biochemical studies involving protein structure, function, and interactions.

Basic Information

Product Name	Fmoc-L-Serine
CAS No.	73724-45-5
Molecular Formula	C18H17NO5
Molecular Weight	327.33 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine; Fmoc-Ser-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-hydroxypropanoic acid; N-Fmoc-L-serine; Fmoc-L-Ser; Fmoc-Ser; N-(9-Fluorenylmethoxycarbonyl)-L-serine; L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-L-Serine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.