Description

L-Methionine-Methyl-13C,Methyl-D3 is a high-purity, stable isotope-labeled derivative of the essential amino acid L-Methionine. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of methionine and its metabolites in complex biological matrices. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and nutritional science industries who require the highest level of analytical reliability and data integrity.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the absolute quantification of L-methionine in pharmacokinetic, metabolomic, and proteomic studies.
• Clinical Research & Diagnostics: Used in the development and validation of assays for monitoring methionine levels related to inborn errors of metabolism, liver function, and nutritional status.
• Pharmaceutical Development: Essential for drug metabolism and pharmacokinetics (DMPK) studies of methionine-containing drugs and peptides, ensuring accurate bioanalytical data for regulatory submissions.
• Nutritional Science & Supplement Analysis: Enables precise measurement of methionine bioavailability and metabolism in fortified foods, infant formula, and dietary supplements.
• Stable Isotope Tracer Studies: Utilized in metabolic flux analysis to trace the incorporation of methionine into proteins, glutathione, and other sulfur-containing compounds in cell culture and animal models.
• Forensic & Doping Control: Applied in specialized testing protocols where isotopic labeling is required for unambiguous identification and quantification.

Basic Information

Product Name	L-Methionine-Methyl-13C,Methyl-D3
CAS No.	73488-65-0
Molecular Formula	C13CH3D3SCH2CH2CH(NH2)COOH
Molecular Weight	154.22 g/mol (approximate)
Synonyms	(2S)-2-Amino-4-((13C)methylsulfanyl)butanoic-3,3,3-d3 acid; L-Methionine (methyl-13C, methyl-d3); L-Methionine-13C,D3; Methionine (methyl-13C, methyl-d3); Stable Isotope Labeled L-Methionine; L-Met-13C,D3; Internal Standard for Methionine; Isotopic Methionine.
EINECS	Contact for details

Quality Control

Every batch of L-Methionine-Methyl-13C,Methyl-D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the isotopic enrichment, chemical purity, and specific analytical results. Our quality commitment ensures the reproducibility and reliability required for sensitive research and regulated analytical work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % D
Optical Rotation	[α]D20: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.