Description

7β-[(Z)-2-(2-Aminothiazol-4-Yl)-2-(1-Carboxy-1-Methylethoxyimino)Acetamido]-3-Acetoxymethyl-3-Cephem-4-Carboxylic Acid is a key advanced pharmaceutical intermediate in the synthesis of third-generation cephalosporin antibiotics. This compound matters because it provides the essential structural core for developing potent, broad-spectrum antibacterial agents with enhanced stability against β-lactamases. Pharmaceutical manufacturers and research institutions require this high-purity intermediate for the development and production of next-generation antibiotic formulations.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a critical intermediate in the manufacture of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Serves as a building block for novel antibiotic candidates in preclinical and clinical studies.
• Antibacterial Drug Production: Used in the commercial-scale synthesis of drugs targeting resistant bacterial infections.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Process Chemistry Optimization: Utilized in scaling up and optimizing synthetic routes for cephalosporin-based therapeutics.

Basic Information

Product Name	7β-[(Z)-2-(2-Aminothiazol-4-Yl)-2-(1-Carboxy-1-Methylethoxyimino)Acetamido]-3-Acetoxymethyl-3-Cephem-4-Carboxylic Acid
CAS No.	73443-60-4
Molecular Formula	C20H21N5O9S2
Molecular Weight	547.54 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-ACA Derivative (Aminothiazolyl Methoxyimino); Cephalosporin C-7 Side Chain Intermediate; ATMO-Cephalosporin Intermediate; (Z)-7β-[2-(2-Aminothiazol-4-yl)-2-(1-Carboxy-1-Methylethoxyimino)Acetamido]-3-(Acetoxymethyl)-3-Cephem-4-Carboxylic Acid
EINECS	Contact for details

Quality Control

Our 7β-[(Z)-2-(2-Aminothiazol-4-Yl)-2-(1-Carboxy-1-Methylethoxyimino)Acetamido]-3-Acetoxymethyl-3-Cephem-4-Carboxylic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available upon request. Production can adhere to cGMP guidelines for API intermediate manufacture.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.