Description

Ceftriaxone CAS NO 73384-59-5 is a broad-spectrum third-generation cephalosporin antibiotic belonging to the β-lactam class. It is valued for its potent bactericidal activity against a wide range of Gram-positive and Gram-negative pathogens, including many resistant strains. This active pharmaceutical ingredient (API) is essential for the formulation of injectable antibiotics used in hospital and clinical settings to treat serious infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations (powder for solution).
• Hospital-Acquired Infections: Treatment of severe infections such as meningitis, sepsis, and complicated urinary tract infections.
• Surgical Prophylaxis: Used to prevent post-operative infections in major surgeries.
• Respiratory Infections: Effective against bacterial pneumonia and other lower respiratory tract infections.
• Bone and Joint Infections: Treatment of osteomyelitis and septic arthritis.
• Gonorrhea Treatment: A first-line therapy for uncomplicated gonococcal infections.
• Veterinary Medicine: Used in the treatment of bacterial infections in animals under veterinary supervision.
• Research & Development: Serves as a reference standard and for the development of new antibiotic formulations or combination therapies.

Basic Information

Product Name	Ceftriaxone
CAS No.	73384-59-5
Molecular Formula	C18H18N8O7S3
Molecular Weight	554.58 g/mol
Synonyms	Ceftriaxone Sodium; Rocephin (brand name); (6R,7R)-7-[[(2Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephriaxone; Cefatriaxone; 7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 72-(Z)-(O-methyloxime); EINECS 277-413-6
EINECS	277-413-6

Quality Control

Our Ceftriaxone is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and JP. Each batch undergoes rigorous analytical testing including HPLC for assay and impurity profiling, microbial limits testing, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) documenting identity, purity, potency, and safety is provided with every shipment to ensure traceability and regulatory compliance for our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under conditions that prevent exposure to excessive humidity.

Specification

Item	Specification
Appearance	White to slightly yellowish crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC, anhydrous basis)	98.0% - 102.0%
pH (1% aqueous solution)	6.0 - 8.0
Water Content (KF)	≤ 11.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.20 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.