Description

(Lys(Z)2)-Tuftsin is a synthetic, protected derivative of the immunomodulatory tetrapeptide tuftsin. This compound is specifically engineered to enhance stability and control reactivity during peptide synthesis and research applications. It serves as a critical intermediate for researchers and manufacturers in the fields of immunology, oncology, and advanced peptide drug development. The product is supplied as a high-purity material to ensure reliable and reproducible experimental and production outcomes.

Application

• Peptide Synthesis Intermediate: A key building block in the solid-phase or solution-phase synthesis of tuftsin analogs and related immunostimulatory peptides.
• Immunological Research: Used in studies investigating macrophage activation, phagocytosis enhancement, and the modulation of innate immune responses.
• Drug Discovery & Development: Serves as a precursor in the development of novel therapeutic agents targeting cancer, infections, and immune disorders.
• Bioconjugation Studies: The protected lysine side chain allows for selective deprotection and conjugation to carriers, labels, or other molecules.
• Structure-Activity Relationship (SAR) Studies: Essential for synthesizing modified tuftsin sequences to elucidate the pharmacophore and optimize biological activity.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control in peptide manufacturing.

Basic Information

Item	Detail
Product Name	(Lys(Z)2)-Tuftsin
CAS No.	73363-35-6
Molecular Formula	C41H58N8O11
Molecular Weight	838.96 g/mol
Synonyms	Nα,Nε-Bis(Z)-L-Lysyl-L-threonyl-L-lysyl-L-proline; Nα,Nε-Bis(benzyloxycarbonyl)-L-lysyl-L-threonyl-L-lysyl-L-proline; H-Lys(Z)-Thr-Lys(Z)-Pro-OH; Tuftsin, Lys(Z)2-; (Lys(Z)2)-Tuftsin acetate; Protected Tuftsin; Thr-Lys-Pro-Arg derivative
EINECS	Contact for details

Quality Control

Our (Lys(Z)2)-Tuftsin is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Quality is verified against stringent in-house specifications using techniques including HPLC, MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.