Description

Boc-D-Pro-Ome CAS NO 73323-65-6 is a high-purity, protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) protected methyl ester of D-proline. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering excellent stereochemical control and protection group stability under standard coupling conditions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing therapeutic peptides, protease inhibitors, and other bioactive molecules where the unique conformational properties of proline are required.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce the D-proline scaffold into novel drug candidates to enhance metabolic stability, bioavailability, and receptor selectivity.
• Protease Inhibitor Development: Serves as a core component in the design and synthesis of inhibitors for various enzymes like ACE, HIV protease, and thrombin.
• Bioconjugation & Labeling: Employed in the preparation of peptide conjugates for diagnostic imaging, targeted drug delivery, and biochemical probes.
• Academic & R&D Laboratories: A fundamental reagent for methodological studies in organic synthesis, asymmetric synthesis, and peptide chemistry.
• Combinatorial Chemistry: Utilized in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	Boc-D-Pro-Ome
CAS No.	73323-65-6
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(R)-1-[(tert-Butoxy)carbonyl]pyrrolidine-2-carboxylic acid methyl ester; Methyl (R)-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylate; Methyl (R)-1-Boc-pyrrolidine-2-carboxylate; (R)-1-Boc-pyrrolidine-2-carboxylic acid methyl ester; D-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-D-proline methyl ester; (R)-1-Boc-2-carbomethoxypyrrolidine; Boc-D-Pro-OMe
EINECS	Contact for details

Quality Control

Our Boc-D-Pro-Ome is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.