Description

6-(5-Cholesten-3 β-Yloxy)Hexyl-1-Thio-α-D-Mannopyranoside is a specialized synthetic glycolipid derivative, combining a cholesterol moiety with a mannose sugar headgroup via a thioether-linked hexyl spacer. This unique molecular architecture makes it a critical tool for membrane research and targeted drug delivery systems. It is primarily utilized by pharmaceutical R&D teams and life science researchers working on liposomal formulations, vaccine adjuvants, and receptor-ligand interaction studies.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: Acts as a functionalized lipid component to introduce mannose targeting ligands onto vesicle surfaces for cell-specific delivery.
• Drug Delivery Targeting: Exploited for targeting mannose-binding receptors (e.g., on antigen-presenting cells) to enhance the cellular uptake of therapeutic cargo.
• Vaccine Adjuvant Development: Used in the design of novel adjuvant systems to direct vaccine antigens to immune cells and potentiate immune responses.
• Membrane Biophysics Research: Serves as a model compound to study the incorporation of glycolipids into lipid bilayers and their effect on membrane properties.
• Glycobiology Studies: A valuable synthetic standard and probe for investigating carbohydrate-protein interactions and lectin binding.
• Diagnostic Agent Conjugation: Provides a platform for conjugating imaging agents or dyes to lipophilic carriers for diagnostic applications.

Basic Information

Product Name	6-(5-Cholesten-3 β-Yloxy)Hexyl-1-Thio-α-D-Mannopyranoside
CAS No.	73294-91-4
Molecular Formula	C39H66O6S
Molecular Weight	662.99 g/mol
Synonyms	Cholesteryl 6-(α-D-Mannopyranosylthio)hexyl Ether; 6-(Cholesteryloxy)hexyl 1-Thio-α-D-mannopyranoside; Cholestenyl Mannoside Derivative; Cholesterol-PEG-Mannose Derivative; α-D-Mannopyranoside, 6-[(3β)-cholest-5-en-3-yloxy]hexyl 1-thio-; Mannose-Cholesterol Conjugate; Thiomannoside-Cholesterol Conjugate; Synthetic Glycolipid 73294-91-4
EINECS	Contact for details

Quality Control

Our 6-(5-Cholesten-3 β-Yloxy)Hexyl-1-Thio-α-D-Mannopyranoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.