Description

12-o-Hexadecanoyl-4-Deoxy-4 α-16-Hydroxyphorbol-13-Acetate is a specific, high-purity derivative of phorbol, a complex diterpene natural product. This compound is of significant interest in advanced biochemical and pharmacological research due to its role as a potent modulator of protein kinase C (PKC) activity. It is primarily utilized by research institutions and pharmaceutical development laboratories for studying signal transduction pathways, cellular proliferation, and tumor promotion mechanisms. The compound's defined structure makes it a critical tool for precise mechanistic studies in cancer biology and toxicology.

Application

• Biochemical Research: As a reference standard and active agent in studies of Protein Kinase C (PKC) activation and related signal transduction cascades.
• Pharmacology & Toxicology: Used in investigative studies on tumor promotion, cell proliferation, and apoptosis to understand carcinogenic mechanisms.
• Drug Discovery: Serves as a key molecular probe or starting point for the development of novel PKC inhibitors or targeted cancer therapies.
• Academic Research: Employed in university and institutional labs for fundamental research in cell biology and molecular pharmacology.
• Standards & Calibration: Used as a high-purity certified reference material (CRM) for analytical method development and validation in regulatory testing.

Basic Information

Product Name	12-o-Hexadecanoyl-4-Deoxy-4 α-16-Hydroxyphorbol-13-Acetate
CAS No.	73089-77-7
Molecular Formula	C38H58O8
Molecular Weight	642.87 g/mol
Synonyms	16-Hydroxyphorbol 12-hexadecanoate 13-acetate; 12-O-Hexadecanoyl-4-deoxy-4α,16-dihydroxyphorbol-13-acetate; 4-Deoxy-4α,16-dihydroxy-12-O-palmitoylphorbol-13-acetate; 12-O-Palmitoyl-4-deoxy-4α,16-dihydroxyphorbol-13-acetate; Phorbol 12-palmitate 13-acetate derivative; 16-Hydroxyphorbol-12-palmitate-13-acetate; 73089-77-7; 4-Deoxy-4α,16-dihydroxyphorbol-12-palmitate-13-acetate
EINECS	Contact for details

Quality Control

Our 12-o-Hexadecanoyl-4-Deoxy-4 α-16-Hydroxyphorbol-13-Acetate is manufactured under strict quality control protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management systems to support research and development needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); it is recommended to store under an inert gas such as argon or nitrogen for long-term stability. Keep container tightly sealed in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.