Description

Tocainide Carbamoyl o-β-Glucuronide is a key metabolite and analytical reference standard derived from the conjugation of tocainide with glucuronic acid. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics (DMPK). It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of tocainide and its metabolites in biological matrices.
• Drug Metabolism Studies: Used in in vitro and in vivo studies to elucidate the Phase II glucuronidation pathway of the antiarrhythmic agent Tocainide.
• Bioanalytical Method Development: Critical for developing and validating robust HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring (TDM) and pharmacokinetic profiling.
• Toxicology and Safety Assessment: Employed as a marker in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the safety and clearance profile of the parent drug.
• Impurity Profiling: Acts as a specified impurity standard in the quality control of Tocainide active pharmaceutical ingredient (API) to ensure product purity and compliance with ICH guidelines.
• Clinical Research: Utilized in clinical trials to accurately measure metabolite concentrations in patient plasma or urine samples.

Basic Information

Product Name	Tocainide Carbamoyl o-β-Glucuronide
CAS No.	73025-66-8
Molecular Formula	C20H29N3O9
Molecular Weight	455.46 g/mol
Synonyms	Tocainide Carbamoyl O-β-D-Glucuronide; Tocainide O-Carbamoyl-β-D-Glucuronide; 2-Amino-N-(2,6-dimethylphenyl)propanamide Carbamoyl Glucuronide; Tocainide Metabolite; Tocainide Glucuronide Metabolite; W-36095 Carbamoyl Glucuronide; (2R,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-((((2-((2,6-dimethylphenyl)amino)propanoyl)carbamoyl)oxy)methoxy)tetrahydro-2H-pyran-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Tocainide Carbamoyl o-β-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay, identity confirmation (IR, MS), and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical reference materials. Comprehensive Certificates of Analysis (COA) with batch-specific data are provided to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.