Description

Dextran-Maleimide CAS NO 73019-87-1 is a functionalized polysaccharide derivative where maleimide groups are covalently attached to a dextran backbone. This modification is critical as it introduces a highly reactive handle for site-specific conjugation with thiol-containing molecules via the Michael addition reaction. It is an essential building block for researchers and manufacturers in the life sciences sector who require precise and stable bioconjugation strategies. This product enables the creation of advanced drug delivery systems, diagnostic reagents, and functional biomaterials.

Application

• Bioconjugation and Protein Modification: Site-specific coupling of peptides, proteins, antibodies, or enzymes via free thiol groups for creating stable conjugates.
• Drug Delivery System Development: Synthesis of polymer-drug conjugates where therapeutics are linked to the dextran-maleimide carrier for targeted or sustained release.
• Diagnostic Reagent Formulation: Preparation of labeled probes and assay components, such as enzyme-linked or fluorescently tagged detection molecules.
• Hydrogel and Biomaterial Fabrication: Cross-linking agent for creating thiol-functionalized hydrogels used in tissue engineering and 3D cell culture scaffolds.
• Surface Functionalization: Immobilization of biomolecules onto thiolated surfaces, chips, or nanoparticles for biosensor and microarray applications.
• Affinity Chromatography Media: Ligand attachment for the preparation of specialized chromatography resins used in protein purification.

Basic Information

Product Name	Dextran-Maleimide
CAS No.	73019-87-1
Molecular Formula	(C6H10O5)n·(C4H2O3)m
Molecular Weight	Varies by dextran chain length and degree of maleimide substitution. Contact for details.
Synonyms	Maleimide-functionalized Dextran; Dextran-Maleimide Conjugate; Maleimido-dextran; Dextran Maleimide Derivative; Dextran-Mal; Dex-MAL; Poly-Dextran Maleimide
EINECS	Contact for details.

Quality Control

Our Dextran-Maleimide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure consistent performance in conjugation applications. Key parameters such as degree of substitution (DS), molecular weight distribution, and functional group integrity are verified. Certificates of Analysis (COA) detailing purity, substitution level, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (IR)	Conforms to structure
Dextran Backbone MW	10 kDa, 40 kDa, 70 kDa, or custom (Typical)
Degree of Substitution (DS)	0.1 - 0.5 maleimide groups per glucose unit (Customizable)
Assay (Functional Group)	> 85% (by titration or NMR)
Solvent Content (Residual)	< 5% (by Karl Fischer or TGA)
Biological Safety (Endotoxin)	< 1.0 EU/mg (for research-grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.