Description

3-(Trifluoromethyl)Isatoic Anhydride is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the anhydride moiety combined with the electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl group. This compound is essential for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials who require high-purity, reliable intermediates to drive innovation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of quinazolinone and quinoline-based drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in constructing novel herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a monomer or cross-linking agent for developing specialty polymers with enhanced thermal and chemical resistance.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport materials and host molecules for display technologies.
• Fluorescent Dye & Sensor Development: Acts as a core structure for creating advanced fluorophores and chemosensors used in bioimaging and diagnostics.
• Peptide & Protein Modification: Utilized for introducing the trifluoromethyl group into biomolecules to study structure-activity relationships.

Basic Information

Product Name	3-(Trifluoromethyl)Isatoic Anhydride
CAS No.	72985-50-3
Molecular Formula	C9H4F3NO3
Molecular Weight	231.13 g/mol
Synonyms	3-(Trifluoromethyl)-1H-benzo[d][1,3]oxazine-2,4-dione; 3-(Trifluoromethyl)-2H-3,1-benzoxazine-2,4(1H)-dione; 3-Trifluoromethylisatoic Anhydride; 3-Trifluoromethyl-1H-3,1-benzoxazine-2,4-dione; Isatoic Anhydride, 3-(trifluoromethyl)-; 3-(Trifluoromethyl)anthranilic Acid N-Carboxyanhydride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Isatoic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.