Description

Furosemide Acyl-B-D-Glucuronide is a major, pharmacologically active metabolite of the loop diuretic furosemide. This compound is of critical importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It serves as a vital reference standard for analytical laboratories in pharmaceutical, clinical, and forensic toxicology sectors requiring precise quantification and identification of furosemide and its metabolites in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, bioavailability, and excretion profiles of furosemide.
• Bioanalytical Assay Development: Used to develop and optimize HPLC, LC-MS/MS, and other chromatographic assays for therapeutic drug monitoring (TDM).
• Clinical Research: Enables accurate measurement of metabolite levels in plasma, serum, and urine during clinical trials.
• Forensic and Doping Control Analysis: A key analyte for the detection and confirmation of furosemide use in forensic toxicology and anti-doping programs.
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of furosemide drug substances and products.

Basic Information

Product Name	Furosemide Acyl-B-D-Glucuronide
CAS No.	72967-59-0
Molecular Formula	C23H26ClN2O11S
Molecular Weight	585.98 g/mol
Synonyms	Furosemide Acyl Glucuronide; Furosemide 1-O-Acyl-β-D-Glucuronide; 4-Chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid 1-(β-D-glucopyranuronosyl) ester; Furosemide Glucuronide; Lasix Metabolite; Frusemide Acyl Glucuronide; 1-O-Acyl-β-D-Glucuronide of Furosemide
EINECS	Contact for details

Quality Control

Every batch of Furosemide Acyl-B-D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide high-purity material suitable for use as an analytical reference standard, with comprehensive characterization including HPLC purity, NMR, and MS confirmation. A detailed Certificate of Analysis (COA) containing batch-specific data is supplied with each shipment to ensure traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain integrity. Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.