Description

Ethyl(2R)-2-Fluoropropanoate is a high-purity chiral building block and fluorinated intermediate of significant importance in advanced organic synthesis. Its value lies in the introduction of a fluorine atom in a stereochemically defined manner, which is critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key precursor for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides where the fluorine atom enhances efficacy and environmental persistence.
• Asymmetric Synthesis: Serves as a versatile electrophile or nucleophile in stereoselective reactions, including alkylations and cross-couplings, for constructing complex chiral centers.
• Material Science Research: Employed in the synthesis of fluorinated monomers or ligands for specialty polymers and catalysts with unique properties.
• Process Chemistry & Scale-Up: Suitable for use in route scouting and optimization from milligram to kilogram scale under GMP or non-GMP conditions.

Basic Information

Product Name	Ethyl(2R)-2-Fluoropropanoate
CAS No.	72959-94-5
Molecular Formula	C5H9FO2
Molecular Weight	120.12 g/mol
Synonyms	(R)-Ethyl 2-fluoropropanoate; (2R)-2-Fluoropropanoic Acid Ethyl Ester; Ethyl (R)-(-)-2-fluoropropionate; (R)-(-)-2-Fluoropropionic Acid Ethyl Ester; Ethyl (R)-2-fluoropropionate; (R)-2-Fluoropropionic Acid Ethyl Ester; FAEE (2R-F); Propanoic acid, 2-fluoro-, ethyl ester, (2R)-
EINECS	Contact for details

Quality Control

Our Ethyl(2R)-2-Fluoropropanoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing specifications such as assay, enantiomeric excess (ee), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its high volatility and sensitivity to strong alkali/organic solvents, keep away from heat, sparks, and open flames. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.