Description

(S)-n-(2,2-Dimethyl-1[1,3]Dioxolan-4-Ylmethyl)-Acetamide is a chiral acetamide derivative featuring a protected diol moiety, making it a valuable synthetic intermediate. This compound is crucial for the stereoselective synthesis of complex molecules, particularly in the pharmaceutical sector where chirality is essential for biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of enantiomerically pure drugs, particularly those targeting the central nervous system or as enzyme inhibitors.
• Asymmetric Synthesis: Used in the preparation of chiral ligands, catalysts, and auxiliaries for stereocontrolled chemical reactions.
• Fine Chemical Production: Serves as a precursor for the manufacture of complex agrochemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial Research: Employed in medicinal chemistry programs for lead optimization and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used for scaling up synthetic routes to chiral targets, aiding in the development of cost-effective and efficient manufacturing processes.

Basic Information

Product Name	(S)-n-(2,2-Dimethyl-1[1,3]Dioxolan-4-Ylmethyl)-Acetamide
CAS No.	72952-75-1
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	(S)-N-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methylacetamide; (S)-Acetamide, N-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-; (4S)-2,2-Dimethyl-4-(acetamidomethyl)-1,3-dioxolane; (S)-1-(2,2-Dimethyl-1,3-dioxolan-4-yl)-N-methylacetamide (common misnomer); (S)-Acetamidomethyl-2,2-dimethyl-1,3-dioxolane; (S)-Dioxolane acetamide derivative; (S)-Protected serinol acetamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥98% (by HPLC), with enantiomeric excess (ee) specifications available to meet stringent chiral purity requirements. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.