Description

Technetium Tc 99M Hydroxymethylene Diphosphonate is a diagnostic radiopharmaceutical agent, a complex of metastable technetium-99m with a bisphosphonate derivative. This compound is critically important for its role in nuclear medicine imaging, specifically for skeletal scintigraphy. It is primarily needed by radiopharmacies, nuclear medicine departments in hospitals, and diagnostic imaging centers for the detection of bone metastases, infections, and other skeletal pathologies.

Application

• Bone Scintigraphy (Bone Scan): The primary application for detecting areas of abnormal bone metabolism associated with metastases, fractures, infections (osteomyelitis), and arthritis.
• Oncological Diagnostics: Essential for staging and monitoring cancers known to metastasize to bone, such as breast, prostate, and lung cancer.
• Evaluation of Pain: Used to investigate unexplained bone pain and identify potential underlying skeletal lesions.
• Infection Imaging: Aids in the diagnosis of bone and joint infections when combined with other imaging modalities.
• Assessment of Prosthetic Joints: Helps evaluate potential loosening or infection of artificial joints.
• Paget's Disease Assessment: Useful for determining the extent and activity of Paget's disease of bone.
• Pediatric Skeletal Disorders: Applied in the evaluation of child-specific conditions like child abuse, Legg-Calvé-Perthes disease, and growth plate injuries.

Basic Information

Product Name	Technetium Tc 99M Hydroxymethylene Diphosphonate
CAS No.	72945-61-0
Molecular Formula	C2H8O10P2Tc
Molecular Weight	Contact for details
Synonyms	Technetium Tc 99m Oxidronate; Tc-99m HDP; Technetium (99mTc) Oxidronate; Hydroxymethylene Diphosphonate, Technetium Tc 99m Complex; HMDP (Tc-99m); 99mTc-HMDP; Oxidronate Sodium Tc 99m; Kit for the preparation of Technetium Tc 99m Oxidronate
EINECS	Contact for details

Quality Control

Our radiopharmaceutical products are manufactured under strict quality systems. Each batch of Technetium Tc 99M Hydroxymethylene Diphosphonate is tested to ensure compliance with pharmacopoeial standards (e.g., USP, Ph. Eur.) for critical parameters including radiochemical purity, radionuclidic purity, pH, and sterility. Certificates of Analysis (COA) detailing all release specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as directed. The product is strictly light-sensitive and must be protected from all light exposure during storage and handling to maintain stability and radiochemical purity.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
pH	5.0 - 7.0
Radiochemical Purity (HPLC/TLC)	≥ 90%
Radionuclidic Purity (γ-ray spectrometry)	≥ 99.9% (Tc-99m)
Chemical Purity	Meets established limits
Sterility Test	Sterile
Bacterial Endotoxins	< 175 EU/Vial

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.