Description

n-Despropyl Pergolide is a key pharmaceutical intermediate and a structural analog of the dopamine agonist Pergolide. This compound is of significant value in advanced organic synthesis and medicinal chemistry research, particularly for the development and study of dopaminergic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) therapeutics and novel chemical entities.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Pergolide and related dopaminergic compounds.
• Medicinal Chemistry Research: Used as a reference standard or precursor in structure-activity relationship (SAR) studies for CNS targets.
• Biochemical Research: Serves as a tool compound for investigating dopamine receptor interactions and signaling pathways.
• Process Development: Employed in the optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Analytical Standard: Used for method development, validation, and quality control testing in analytical laboratories.

Basic Information

Item	Detail
Product Name	n-Despropyl Pergolide
CAS No.	72821-91-1
Molecular Formula	C15H20N2S
Molecular Weight	260.40 g/mol
Synonyms	8β-[(Methylthio)methyl]-6-propylergoline; Pergolide Despropyl; Despropylpergolide; 1-[(6-Propyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)methyl]-methylsulfane; 6-Propyl-8β-[(methylthio)methyl]ergoline; LY-127809 Despropyl Analog
EINECS	Contact for details

Quality Control

Our n-Despropyl Pergolide is manufactured under a quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents is provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.