Description

Phenylalanine Phosphoramidate Phenyl Ester is a specialized, high-purity chemical building block of significant importance in advanced organic synthesis. Its primary value lies in its role as a key intermediate for the preparation of modified peptides and nucleotide analogs, enabling critical research and development. This compound is essential for pharmaceutical R&D teams, biotechnology firms, and academic institutions focused on medicinal chemistry, proteomics, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of peptide-based drug candidates and prodrugs.
• Protease Inhibitor Research: Used in the development and study of enzyme inhibitors targeting specific proteolytic pathways.
• Peptide Modification: Enables site-specific phosphorylation or phosphoramidate incorporation into peptide chains for structure-activity relationship (SAR) studies.
• Nucleotide Analog Synthesis: Serves as a precursor in the creation of modified nucleotides for antisense oligonucleotide or siRNA research.
• Bioconjugation Chemistry: Utilized for attaching peptides or other molecules to surfaces, polymers, or biomolecules via its reactive ester group.
• Medicinal Chemistry & Lead Optimization: A valuable tool for medicinal chemists to introduce phosphoramidate motifs into lead compounds to modulate bioavailability and metabolic stability.

Basic Information

Item	Details
Product Name	Phenylalanine Phosphoramidate Phenyl Ester
CAS No.	72772-29-3
Molecular Formula	C15H17N2O5P
Molecular Weight	336.28 g/mol
Synonyms	Phenyl L-Phenylalaninyl Phosphoramidate Phenyl Ester; L-Phenylalanine, P-[(phenylamino)phosphinyl]-, phenyl ester; Phenyl (Phenyl-L-phenylalanyl)phosphoramidate; Phosphoramidic acid, P-phenyl-, 1-(1-oxo-3-phenyl-2-[(phenylamino)phosphinyl]amino]propyl) phenyl ester; Phenyl N-(1-Oxo-3-phenyl-2-[(phenylamino)phosphinyl]amino]propyl)-L-phenylalaninate; Phenylalaninylphosphoramidate Phenyl Ester; Fmoc-Phe-PA-OPhe (in certain protecting group contexts); A phosphoramidate derivative of phenylalanine phenyl ester.
EINECS	Contact for details

Quality Control

Our Phenylalanine Phosphoramidate Phenyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., argon or nitrogen) in a desiccator to maintain stability and purity. Avoid prolonged exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.