Description

Insulin, Gln(B13)- CAS NO 72751-52-1 is a specifically modified insulin analog where the amino acid at position B13 has been substituted with glutamine. This engineered peptide is a critical research-grade material for advancing the understanding of insulin structure, function, and receptor interaction dynamics. It is essential for scientists and developers in the fields of diabetes research, metabolic disorder studies, and novel therapeutic peptide development. The compound serves as a fundamental tool for investigating insulin signaling pathways and for the rational design of next-generation insulin-based pharmaceuticals.

Application

• Biochemical and Pharmaceutical Research: Used as a reference standard and active material in studies of insulin's mechanism of action, stability, and receptor binding affinity.
• Structure-Activity Relationship (SAR) Studies: Critical for investigating how specific amino acid modifications affect insulin's biological potency and physical properties.
• Analytical Method Development: Serves as a calibrant and test compound in the development and validation of HPLC, LC-MS, and other analytical techniques for peptide analysis.
• Preclinical Development: Employed in early-stage in vitro and in vivo studies to evaluate the efficacy and pharmacokinetics of modified insulin analogs.
• Educational and Reference Material: Supplied to academic and institutional laboratories for teaching and advanced research in endocrinology and peptide chemistry.

Basic Information

Product Name	Insulin, Gln(B13)- CAS NO 72751-52-1
CAS No.	72751-52-1
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Gln(B13)-Insulin; Insulin (Gln at B13); B13-Glutamine Insulin; Insulin analog [GlnB13]; [Gln13]-Insulin B-chain; Insulin B Chain (Gln13); 72751-52-1; Insulin, Gln(B13)-
EINECS	Contact for details

Quality Control

Our research-grade Insulin, Gln(B13)- is produced and handled under strict quality protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from key tests including HPLC purity, peptide content, and mass spectrometry (MS) confirmation. We adhere to rigorous in-house standards suitable for critical research applications, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.