Description

(6R,7R)-7-[[(2Z)-2-(2-Amino-4-Thiazolyl)-2-[(Carboxymethoxy)Imino]Acetyl]Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. It is a critical building block for the synthesis of third-generation cephalosporin antibiotics, offering a key structural component for broad-spectrum activity. This compound is essential for manufacturers in the pharmaceutical industry engaged in the research, development, and production of potent antibacterial APIs.

Application

• Primary Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for manufacturing third-generation cephalosporin antibiotics such as Cefotaxime and Ceftriaxone.
• Pharmaceutical Research & Development: Serves as a key starting material in medicinal chemistry for developing novel β-lactam antibiotics with improved efficacy.
• Antibacterial Drug Production: Used in the commercial-scale synthesis of injectable antibiotic formulations targeting resistant bacterial infections.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and regulatory testing of cephalosporin products.
• Process Chemistry Optimization: Utilized in scaling up and optimizing synthetic routes for cephalosporin manufacturing to improve yield and purity.

Basic Information

Product Name	(6R,7R)-7-[[(2Z)-2-(2-Amino-4-Thiazolyl)-2-[(Carboxymethoxy)Imino]Acetyl]Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	72701-01-0
Molecular Formula	C16H17N5O7S2
Molecular Weight	455.47 g/mol
Synonyms	7-ACA Derivative (Cefotaxime Acid); (6R,7R)-3-Methyl-8-oxo-7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefotaxime Intermediate; 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefotaxime Nucleus; 7-ACA-Thiazole Derivative; CEOT
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-[[(2Z)-2-(2-Amino-4-Thiazolyl)-2-[(Carboxymethoxy)Imino]Acetyl]Amino]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Specific Rotation	+55° to +65° (c=1, in water)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Total impurities ≤ 1.5%; Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.