Description

L-Valine Tert.Butyl Amide is a specialized chiral building block and protected amino acid derivative. This compound is of significant value in the synthesis of complex organic molecules, particularly in the pharmaceutical and biotechnology sectors, where high stereochemical purity is paramount. It serves as a critical intermediate for researchers and manufacturers developing peptide-based therapeutics, active pharmaceutical ingredients (APIs), and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide drugs, protease inhibitors, and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected valine derivative to control regioselectivity.
• Chemical Research: Serves as a valuable building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• API Development: Employed in the scalable synthesis of Active Pharmaceutical Ingredients (APIs) requiring high enantiomeric purity.
• Bioconjugation: Useful in the preparation of modified peptides and protein conjugates for diagnostic and therapeutic applications.
• Asymmetric Catalysis: Can be utilized as a precursor for chiral ligands or auxiliaries in asymmetric synthesis.

Basic Information

Product Name	L-Valine Tert.Butyl Amide
CAS No.	72669-49-9
Molecular Formula	C9H20N2O
Molecular Weight	172.27 g/mol
Synonyms	(S)-2-Amino-3-methyl-N-(tert-butyl)butanamide; L-Valine N-tert-Butylamide; N-(tert-Butyl)-L-valinamide; tert-Butylamide of L-Valine; Valine tert-butylamide; (S)-2-Amino-N-(tert-butyl)-3-methylbutanamide; L-Valine tert-Butyl Amide; L-Val-tBu-NH2
EINECS	Contact for details

Quality Control

Our L-Valine Tert.Butyl Amide is produced under strict quality management systems. We offer material suitable for research and GMP-grade applications, with specifications typically meeting or exceeding 98% purity (HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.