Description

Gadoteric Acid CAS NO 72573-82-1 is a high-purity, non-ionic gadolinium-based complex used as a key pharmaceutical intermediate. Its primary value lies in its role as the active pharmaceutical ingredient (API) precursor for gadolinium-based contrast agents (GBCAs) used in magnetic resonance imaging (MRI). This compound is essential for manufacturers in the diagnostic imaging and pharmaceutical sectors who require a reliable, high-quality source for producing safe and effective MRI contrast media.

Application

• Primary raw material for synthesizing Gadoteric Acid meglumine salt (Gadoterate meglumine), a widely used MRI contrast agent.
• Active Pharmaceutical Ingredient (API) intermediate in the production of macrocyclic GBCAs such as Dotarem® and Clariscan®.
• Critical component in diagnostic imaging formulations for enhanced visualization of blood vessels and organs.
• Used in pharmaceutical research and development for new contrast media and therapeutic applications.
• Starting material for the preparation of other gadolinium chelates with specific targeting or imaging properties.
• Reference standard in quality control laboratories for analytical method development and validation.

Basic Information

Product Name	Gadoteric Acid
CAS No.	72573-82-1
Molecular Formula	C16H23GdN4O8
Molecular Weight	558.63 g/mol
Synonyms	Gadoterate Acid; (4R)-4-[(Carboxy-kO)methyl]-7,10-bis(carboxylatomethyl)-1,4,7,10-tetraazacyclododec-1-yl-k4N1,N4,N7,N10acetato(3-)-kO1,kO2,kO4]gadolinium; Gadolinium(III) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; DOTA-Gd; Gd-DOTA; Gadolinium DOTA; Gadoterate; Dotarem Acid Form
EINECS	Contact for details

Quality Control

Our Gadoteric Acid is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including assay, impurity profiling, and residual solvent analysis, to ensure compliance with ICH guidelines and relevant pharmacopeial monographs. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Free Gadolinium	≤ 0.1%
pH (1% solution)	5.0 - 7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.