Description

(S)-1-Cbz-2-Cyanomethylpyrrolidine CAS NO 72500-25-5 is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its core utility lies in its stereochemically defined pyrrolidine scaffold and protected amine functionality, enabling the efficient synthesis of complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for constructing novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained proline-like structures into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile starting material or chiral auxiliary in catalytic asymmetric transformations.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure pesticides and herbicides.
• Chemical Biology Probes: Utilized for creating labeled or tagged compounds for target identification and mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing APIs (Active Pharmaceutical Ingredients) under cGMP.

Basic Information

Product Name	(S)-1-Cbz-2-Cyanomethylpyrrolidine
CAS No.	72500-25-5
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-2-(cyanomethyl)pyrrolidine; (S)-1-Carbobenzoxy-2-cyanomethylpyrrolidine; (S)-N-Cbz-2-Cyanomethylpyrrolidine; (S)-1-(Benzyloxycarbonyl)-2-(cyanomethyl)pyrrolidine; (S)-2-(Cyanomethyl)-1-[(phenylmethoxy)carbonyl]pyrrolidine; (S)-1-Cbz-2-(Cyanomethyl)pyrrolidine; (S)-Pyrrolidine, 1-[(phenylmethoxy)carbonyl]-2-(cyanomethyl)-, (2S)-; Z-(S)-2-Cyanomethylpyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-1-Cbz-2-Cyanomethylpyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, to ensure identity, purity, and enantiomeric excess meet stringent specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.