Description

(S)-5-Oxo-2-Pyrrolidineacetonitrile is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure drugs, particularly in neurological and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced, optically active pesticides and herbicides.
• Asymmetric Catalysis: Serves as a precursor or ligand in catalytic systems for stereoselective chemical transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring high optical purity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry laboratories.

Basic Information

Product Name	(S)-5-Oxo-2-Pyrrolidineacetonitrile
CAS No.	72479-06-2
Molecular Formula	C6H8N2O
Molecular Weight	124.14 g/mol
Synonyms	(S)-2-(Cyanomethyl)pyrrolidin-5-one; (S)-5-Oxopyrrolidine-2-acetonitrile; (S)-2-(Cyanomethyl)-2-pyrrolidinone; (S)-2-Pyrrolidinone-2-acetonitrile; (S)-α-(Cyanomethyl)-γ-butyrolactam; (S)-NSC 334913; (S)-L-Pyroglutaminonitrile
EINECS	Contact for details

Quality Control

Our (S)-5-Oxo-2-Pyrrolidineacetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high optical purity. Quality is verified through comprehensive analytical methods including chiral HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.