Description

2-Succinylbenzoyl-Coenzyme A is a specialized biochemical intermediate, a key substrate in the study of bacterial menaquinone (vitamin K2) biosynthesis. This compound matters for researchers and manufacturers requiring high-purity, well-characterized coenzyme A derivatives for enzymatic assays and metabolic pathway analysis. It is primarily needed by the life science research, pharmaceutical development, and biotechnology industries for applications in enzymology and microbial metabolism studies.

Application

• Enzymatic Research Substrate: Critical for in vitro studies of MenH (2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase) and related enzymes in the menaquinone biosynthetic pathway.
• Metabolic Pathway Analysis: Used to investigate and elucidate bacterial isochorismate metabolism and the synthesis of essential quinones.
• Biochemical Assay Development: Serves as a standard or key reagent in developing high-throughput screening assays for antibiotic target identification.
• Pharmaceutical R&D: Employed in drug discovery programs targeting bacterial metabolism, particularly for novel antibiotic development.
• Academic Research: A vital tool for university and institutional labs studying microbial biochemistry and coenzyme A-dependent reactions.
• Reference Standard: Used as a certified reference material (CRM) for analytical method validation in quality control laboratories.

Basic Information

Product Name	2-Succinylbenzoyl-Coenzyme A
CAS No.	72471-59-1
Molecular Formula	C32H48N7O19P3S
Molecular Weight	959.79 g/mol
Synonyms	2-Succinylbenzoyl-CoA; o-Succinylbenzoyl-Coenzyme A; OSB-CoA; 2-(3-Carboxy-3-oxopropyl)benzoyl-CoA; 2-(3-Carboxypropanoyl)benzoyl-coenzyme A; (2-{3-[(2-{[(3S)-3-Hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxobutanoyl)amino]ethyl}sulfanyl)propyl]amino}butyl]oxy}(hydroxy)phosphoryl]oxy}ethyl)carbamoyl)benzoic acid
EINECS	Contact for details

Quality Control

Our 2-Succinylbenzoyl-Coenzyme A is produced under stringent quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC purity analysis, NMR structural confirmation, and mass spectrometry (MS) to ensure identity and potency. Certificates of Analysis (COA) detailing all test results are available upon request. We support research and cGMP-grade manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into single-use vials to minimize freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Functional as substrate for MenH enzyme (data provided)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.