Description

3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,3-Methyl-,Methylester,[1R-(1-α-,2-Bta-,5-α-)]-(9Ci) is a high-purity, stereochemically defined bicyclic proline derivative, serving as a critical advanced pharmaceutical intermediate (API) and chiral building block. Its rigid, constrained structure is essential for modulating the pharmacokinetic and pharmacodynamic properties of novel therapeutic agents. This compound is primarily utilized by pharmaceutical R&D and contract manufacturing organizations (CMOs) focused on developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly in protease inhibitor and neurological disorder research.
• Peptidomimetics & Constrained Peptide Design: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing specialized chiral ligands and organocatalysts.
• Medicinal Chemistry Scaffold: Employed in fragment-based drug discovery and combinatorial chemistry libraries due to its three-dimensional, sp3-rich character.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential application as a chiral intermediate in the development of novel, enantiomerically pure crop protection agents.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,3-Methyl-,Methylester,[1R-(1-α-,2-Bta-,5-α-)]-(9Ci)
CAS No.	72448-29-4
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	(1R,2S,5R)-3-Methyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester; Methyl (1R,2S,5R)-3-methyl-3-azabicyclo[3.1.0]hexane-2-carboxylate; (1R,2S,5R)-2-(Methoxycarbonyl)-3-methyl-3-azabicyclo[3.1.0]hexane; 3-Methyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester, (1R,2S,5R)-; Bicyclic proline methyl ester derivative; Constrained proline analog
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]hexane derivative is manufactured under strict quality systems. Every batch is subjected to rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.