Description

Prothrombin Fragment 1 is a specific proteolytic cleavage product of prothrombin, a key zymogen in the blood coagulation cascade. This fragment is of significant value in biochemical research and diagnostic applications for studying the mechanisms of coagulation and developing related assays. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science research sectors.

Application

• Biochemical Research: Used as a substrate or standard in studies investigating the intrinsic and extrinsic pathways of blood coagulation.
• Diagnostic Reagent Manufacturing: A critical component in the production of test kits for measuring prothrombin time (PT) and other coagulation factors.
• Enzyme Kinetics Studies: Employed to analyze the kinetics and specificity of thrombin and other serine proteases involved in hemostasis.
• Anticoagulant Drug Development: Serves as a tool for screening and evaluating potential inhibitors of thrombin generation.
• Quality Control Reference: Acts as a reference standard in the quality assurance of therapeutic proteins and plasma-derived products.
• Educational & Clinical Research: Used in academic and clinical laboratory settings to teach and explore disorders of coagulation like thrombosis and hemophilia.

Basic Information

Item	Detail
Product Name	Prothrombin Fragment 1
CAS No.	72270-84-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Prothrombin Fragment 1-2; Activation Fragment 1; Prothrombin Activation Fragment F1; F1 Fragment; Prothrombin 1 Fragment; Coagulation Factor II Fragment 1
EINECS	Contact for details

Quality Control

Our Prothrombin Fragment 1 is produced and tested under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological activity, meeting the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), biological activity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification	Conforms (HPLC, Activity)
Purity (HPLC)	≥ 95%
Biological Activity	Assayed
Protein Content	Determined
Solubility	Soluble in aqueous buffers
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.