Description

Substance P (1-7) CAS NO 72226-88-1 is a specific heptapeptide fragment of the full-length neuropeptide Substance P, representing its N-terminal sequence. This fragment is a critical research tool for studying the structure-activity relationships and signaling pathways of Substance P, particularly its interaction with neurokinin-1 (NK-1) receptors. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and peptide-based drug discovery, where precise molecular tools are required to investigate pain mechanisms, inflammation, and neurological disorders.

Application

• Neuroscientific Research: Used as a selective ligand to study the function and binding affinity of the NK-1 receptor subtype.
• Pharmacological Studies: Employed in vitro and in vivo assays to investigate the physiological roles of Substance P fragments in pain transmission and neurogenic inflammation.
• Drug Discovery & Development: Serves as a reference standard and a key intermediate in the design and screening of novel neurokinin receptor antagonists.
• Biochemical Assays: Utilized in enzyme-linked immunosorbent assays (ELISAs) and radioimmunoassays (RIAs) for the quantification and characterization of Substance P-related peptides.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes exploring neuropeptide biology and signal transduction pathways.

Basic Information

Item	Details
Product Name	Substance P (1-7)
CAS No.	72226-88-1
Molecular Formula	C41H61N11O9S
Molecular Weight	884.06 g/mol
Synonyms	Substance P Fragment 1-7; Arg-Pro-Lys-Pro-Gln-Gln-Phe; SP (1-7); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH; Neurokinin P (1-7); Substance P (1-7) amide (common variant); [Arg1, Pro2, Lys3, Pro4, Gln5, Gln6, Phe7]-Substance P
EINECS	Contact for details

Quality Control

Our Substance P (1-7) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and solvent residues to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.