Description

2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique thiadiazole core. This compound is of critical importance for its role as a key building block in the synthesis of modern cephalosporin antibiotics, enabling enhanced efficacy and stability. It is primarily required by manufacturers in the pharmaceutical, fine chemical, and research sectors for the development of next-generation antimicrobial agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of third and fourth-generation cephalosporin antibiotics (e.g., Cefotaxime, Ceftriaxone).
• Antimicrobial Research: Serves as a core scaffold for developing novel antibacterial and antifungal agents targeting resistant pathogens.
• Fine Chemical Synthesis: Used in the preparation of complex molecules requiring the 1,2,4-thiadiazole moiety for biological activity.
• Bioconjugation Chemistry: Potential utility in creating drug-linker systems for targeted therapies due to its reactive functional groups.
• Agrochemical Development: Exploration of derivatives for use in crop protection products, leveraging its heterocyclic structure.

Basic Information

Product Name	2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic Acid
CAS No.	72217-12-0
Molecular Formula	C5H6N4O3S
Molecular Weight	202.19 g/mol
Synonyms	(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic Acid; (5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetic Acid; 2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic Acid; ATMA; Cefotaxime Acid; Cefotaxime Intermediate; Ceftriaxone Intermediate; Synthase Intermediate A
EINECS	Contact for details

Quality Control

Our 2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure it meets the high-purity standards required for pharmaceutical synthesis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every batch upon request, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.